First and Last Name/s of Presenters

Brittany SmithFollow

Participation Type

Paper Talk

Mentor/s

Professor Frank Wang

Location

Panel D: Academic Building SC 122

Start Day/Time

4-20-2018 11:00 AM

End Day/Time

4-20-2018 12:15 PM

Abstract

The purpose of this study is to identify the relationship between exposure of anesthesia and the negative effects on a brain during synaptogenesis preluding to behavioral, intellectual, and emotional repercussions. Preclinical studies ranging from nematodes to non-human primates show accelerated apoptosis in the developing brain that lead to memory and learning deficits (Davidson, 2016). Furthermore, neuronal apoptosis effects memory or learning impairments in infant rats as seen via electron microscopy and observations (Jevtovic-Todorovic et al., 2003). The clinical studies focused on children receiving anesthesia during the synaptogenesis period and tested the changes in behavior, intellect, and emotion. Immediately following the exposure, overall intelligence levels, language scores, and cognition scores decreased, but only intelligence levels rebounded. Duration, dose, agent, and age contribute to the toxicity of anesthesia on the brain. An alternative to general anesthesia, acupuncture anesthesia, decreased the anesthetic dose, pain scores, and postoperative effects. This research provides valuable information regarding the effects of general anesthesia on the brain ranging from nematodes to humans which may impact future medical practices.

College

College of Health Professions

College and Major available

Health Science, Physician Assistant Studies

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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Apr 20th, 11:00 AM Apr 20th, 12:15 PM

General Anesthesia and the Effects on the Developing Brain in Children

Panel D: Academic Building SC 122

The purpose of this study is to identify the relationship between exposure of anesthesia and the negative effects on a brain during synaptogenesis preluding to behavioral, intellectual, and emotional repercussions. Preclinical studies ranging from nematodes to non-human primates show accelerated apoptosis in the developing brain that lead to memory and learning deficits (Davidson, 2016). Furthermore, neuronal apoptosis effects memory or learning impairments in infant rats as seen via electron microscopy and observations (Jevtovic-Todorovic et al., 2003). The clinical studies focused on children receiving anesthesia during the synaptogenesis period and tested the changes in behavior, intellect, and emotion. Immediately following the exposure, overall intelligence levels, language scores, and cognition scores decreased, but only intelligence levels rebounded. Duration, dose, agent, and age contribute to the toxicity of anesthesia on the brain. An alternative to general anesthesia, acupuncture anesthesia, decreased the anesthetic dose, pain scores, and postoperative effects. This research provides valuable information regarding the effects of general anesthesia on the brain ranging from nematodes to humans which may impact future medical practices.