Participation Type

Poster

Mentor/s

Professors Rachel Bowman and Maya Frankfurt

Location

University Commons

Start Day/Time

4-20-2018 1:00 PM

End Day/Time

4-20-2018 3:00 PM

Abstract

Bisphenol-A (BPA), a known hormone disrupter, exposure in adolescent rats, increases anxiety, impairs memory, and decreases dendritic spine density when measured in adolescence and effects extend into adulthood. These studies were conducted in gonadally intact male and female adolescent rats; this leads to the question of the extent to which observed effects are due to BPA exposure versus natural fluctuations in gonadal hormones. Additionally, estrogen (E) is neuroprotective, enhances memory, and increases dendritic spine density in adult and aging rats; however, E replacement studies in adolescence are limited. Thus, we have conducted a series of experiments in Ovariectomized (OVX) females that examine: (1) effects of adolescent BPA and E exposure on neuronal architecture in the adolescent brain (2) effects of adolescent BPA and E exposure on behavioral measures of anxiety, cognitive performance, and spine density in adolescence

(3) whether possible effects observed in #2 are maintained when measured in adulthood

College

College of Arts and Sciences

College and Major available

Biology, Psychology

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Comments

Jennifer Hagedorn: Neuroscience

Christina Kitakis: Psychology

Emma Madden: Biology

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Apr 20th, 1:00 PM Apr 20th, 3:00 PM

Lasting Effects of Estrogen and Bisphenol-A Exposure During Adolescent Development on Dendritic Spines and Behaviors in Adulthood

University Commons

Bisphenol-A (BPA), a known hormone disrupter, exposure in adolescent rats, increases anxiety, impairs memory, and decreases dendritic spine density when measured in adolescence and effects extend into adulthood. These studies were conducted in gonadally intact male and female adolescent rats; this leads to the question of the extent to which observed effects are due to BPA exposure versus natural fluctuations in gonadal hormones. Additionally, estrogen (E) is neuroprotective, enhances memory, and increases dendritic spine density in adult and aging rats; however, E replacement studies in adolescence are limited. Thus, we have conducted a series of experiments in Ovariectomized (OVX) females that examine: (1) effects of adolescent BPA and E exposure on neuronal architecture in the adolescent brain (2) effects of adolescent BPA and E exposure on behavioral measures of anxiety, cognitive performance, and spine density in adolescence

(3) whether possible effects observed in #2 are maintained when measured in adulthood

 

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