Title

Evaluating Amyloid Beta (Aβ) 1-40 Degradation by Capillary Electrophoresis

Document Type

Article

Publication Date

2013

Abstract

Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1–40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small quantities of a commercially available substrate whose physiological accumulation is thought to underlie the development of Alzheimer’s disease.

Comments

Originally published:

Apler, Benjamin J., Schmidt, Walter K. "Evaluating Amyloid Beta (Aβ) 1-40 Degradation by Capillary Electrophoresis." Methods in Molecular Biology 948 (2013): 263-273.

doi: 10.1007/978-1-62703-296-4_19.