Title

Sir2 Function in Genome Integrity

Date of Award

11-2014

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Benjamin J. Alper

Abstract

The fission yeast Schizosaccharomyces pombe is a common model for studies of eukariotic chromosome function. In this study, we have used the fission yeast model to investigate the function of the NAD-dependent histone deacetylase Sir2 in chromosome segregation and genome integrity.

Comments

Master's thesis submitted to the Faculty of the Sacred Heart University Department of Chemistry in partial fulfillment of the requirements for the degree Master of Science in Chemistry.