Title

Targeted Control of Gene Expression by the Sir2 Histone Deacetylase

Date of Award

8-2014

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Benjamin J. Alper

Abstract

Members of the Sir2 family of NAD-dependent histone deacetylases are critical to regulation of gene expression in many organisms. In humans, the regulation of gene expression is critical to development and normal cellular function... This study seeks to investigate the role played by Sir2 in gene silencing in fission yeast, a common eukaryotic model.

Comments

Master's thesis submitted to the faculty of the Sacred Heart University Department of Chemistry in partial fulfillment of the requirements for the degree Master of Science in Chemistry.