Document Type

Peer-Reviewed Article

Publication Date

10-2007

Abstract

The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.

Comments

Published: Antshel, Kevin, et al. "Autistic Spectrum Disorders in Velo-cardio Facial Syndrome (22q11.2 Deletion)." Journal of Autism and Developmental Disorders 37.9 (2007):1776–1786.

DOI

10.1007/s10803-006-0308-6

PMID

17180713

Publication

Journal of Autism and Developmental Disorders

Volume

37

Issue

9

Publisher

Springer International Publishing

Pages

1776-1786

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