Using Factorial Design and Analysis to Determine the Factors that Affect the Yield of the Oxidation of 1-Indanol to 1-Indanone

Date of Award


Degree Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Linda Farber


Oxidation reactions of 1-Indanol to 1-Indanone using chromium trioxide resin in methylene chloride solvent were studied. The reactions were carried out under reflux at different temperatures and times. Factorial design was used to design reactions that simultaneously tested what effect variables, time and temperature, have on percent conversion of 1-Indanol to 1-Indanone. Eight different combinations of varying time and temperature were designed. Each set of reaction conditions were run three times for a total of twenty-four experiments. A temperature of heat level five and a time of thirty minutes yielded the highest percent conversion of 1-Indanol to 1-Indanone. Percent conversion, spectral analysis and MiniTab software analysis were all used to analyze the factorial design experiments. All showed that time then temperature had the most effect on the percent conversion of 1-Indanol to 1-Indanone.


Master's thesis submitted to the Faculty of the Department of Chemistry at Sacred Heart University in partial fulfillment of the requirements for the degree of Master of Science.