Using Factorial Design and Analysis to Determine the Factors that Affect the Yield of the Oxidation of 1-Indanol to 1-Indanone
Date of Award
Master of Science (MS)
Dr. Linda Farber
Oxidation reactions of 1-Indanol to 1-Indanone using chromium trioxide resin in methylene chloride solvent were studied. The reactions were carried out under reflux at different temperatures and times. Factorial design was used to design reactions that simultaneously tested what effect variables, time and temperature, have on percent conversion of 1-Indanol to 1-Indanone. Eight different combinations of varying time and temperature were designed. Each set of reaction conditions were run three times for a total of twenty-four experiments. A temperature of heat level five and a time of thirty minutes yielded the highest percent conversion of 1-Indanol to 1-Indanone. Percent conversion, spectral analysis and MiniTab software analysis were all used to analyze the factorial design experiments. All showed that time then temperature had the most effect on the percent conversion of 1-Indanol to 1-Indanone.
Alshehri, Amal Ali, "Using Factorial Design and Analysis to Determine the Factors that Affect the Yield of the Oxidation of 1-Indanol to 1-Indanone" (2020). Chemistry Master’s Theses. 25.