DigitalCommons@SHU

Molecular Structure from Models to Mastery: An Inquiry-Based Study of Human Insulin-Degrading Enzyme, Michael A. Araujo, Alexandra A. Barrere, Selena-Rae Tirado, Candace E. Williams, Monica I. Strada, Benjamin Alper
Benjamin Alper

Identification of Malonic Acid as an Inhibitor of Mammalian Arginase I, Maryam Ahmad Khalhamdi
Chemistry Master’s Theses

Characterization of Ghrelin as a Novel Insulin-Degrading Enzyme Substrate, David Daniel Bocach
Chemistry Master’s Theses

Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy., Jillian E. Smith-Carpenter, Benjamin J. Alper
Benjamin Alper

Integrated Screening for Arginase Inhibitors, Hatoon Albilady
Chemistry Master’s Theses

Quantitative Detection of Free Proline as a Marker for Haze Stability in Beer, Philip Marco Gelineau
Chemistry Master’s Theses

Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum., Christopher P. Pratt, Dika A. Kuljis, Gregg E. Homanics, Jianjun He, Dmytro Kolodieznyi, Srikanth Dudem, Mark A. Hollywood, Alison L. Barth, Marcel P. Bruchez
Dika Kuljis

Kinetic Studies of Glutathione S-Transferase, Lazaros Stefanidis
Chemistry Master’s Theses

Predicting OppA Protein-Peptide Binding Affinities from X-ray and Docked Structures, Fatimah Alhazmi
Chemistry Master’s Theses

Predicting and Comparing Binding Affinities from OppA X-ray Crystal and Docked Structures, Marwah Alhujayri
Chemistry Master’s Theses

Efficient synthesis of α-fluoromethylhistidine di-hydrochloride and demonstration of its efficacy as a glutathione S-transferase inhibitor., Kelly L. Considine, Lazaros Stefanidis, Karl G. Grozinger, Joseph Audie, Benjamin J. Alper
Benjamin Alper

Efficient synthesis of α-fluoromethylhistidine di-hydrochloride and demonstration of its efficacy as a glutathione S-transferase inhibitor., Kelly L. Considine, Lazaros Stefanidis, Karl G. Grozinger, Joseph Audie, Benjamin J. Alper
Joseph Audie

Protein-Peptide Docking: Construction of a Protein-Peptide Database and Docking the Peptides into Target Proteins, Abrar Yahya Almasrahi
Chemistry Master’s Theses

Using Chemical Library Screening and a Validated Docking Procedure to Identify Novel Aminoimidazole-based Human Arginase I Inhibitors, Angelica Tescione
Chemistry Master’s Theses

Discovery of a Novel Arginase I Inhibitors by a Validated Virtual Screening and Docking Work-Flow, Brianna Baribault
Chemistry Master’s Theses

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases, Byung Hak Ha, Elizabeth M. Luoma, Benjamin E. Turk, Titus J. Boggon
Elizabeth Luoma, Ph.D.

Targeted Control of Gene Expression by the Sir2 Histone Deacetylase, Najwa Aljehani
Chemistry Master’s Theses

Abstract P348: A Novel Antioxidant Score Independently Predicts CVD Mortality Better than Any Single Antioxidant: Longitudinal Data from the Third National Health and Nutrition Examination Survey (1988-94), Cindy E. McCrea, Jacqueline A. Vernarelli, Penny M. Kris-Etherton, Katherine A. Sauder, Sheila G. West
Jacqueline A. Vernarelli

The Polarized Sorting of Membrane Proteins Expressed in Cultured Hippocampal Neurons Using Viral Vectors, Mark Jareb, Gary Banker
Mark Jareb

Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase., Hitesh Sharma, Mark J. Landau, Todd J. Sullivan, Vidya P. Kumar, Markus K. Dahlgren, William L. Jorgensen, Karen S. Anderson
Todd J. Sullivan

Mutations Affecting a Putative MutLa Endonuclease Motif Impact Multiple DNA Mismatch Repair Functions, Naz Erdeniz, Megan Nguyen, Suzanne M. Deschênes, R. Michael Liskay
Suzanne Deschenes

Intracellular Transport, Assembly, and Degradation of Wild-Type and Disease-linked Mutant Gap Junction Proteins, Judy K. VanSlyke, Suzanne M. Deschênes, Linda S. Musil
Suzanne Deschenes

Using RNAi in C. elegans to Demonstrate Gene Knockdown Phenotypes in the Undergraduate Biology Lab Setting, Nicole Roy
Nicole M. Roy

The Synergistic Use of Computation, Chemistry and Biology to Discover Novel Peptide-Based Drugs: The Time is Right, Joseph Audie, C. Boyd
Joseph Audie

Yeast Ste23p Shares Functional Similarities with Mammalian Insulin-Degrading Enzymes, Benjamin Alper, Jarrad W. Rowse, Walter K. Schmidt
Benjamin Alper

Anion Activation Site of Insulin-Degrading Enzyme, Nicholas Noinaj, Eun Suk Song, Sonia Bhasin, Benjamin J. Alper, Walter K. Schmidt, Louis B. Hersh, David W. Rodgers
Benjamin Alper

Brief Embryonic Strychnine Exposure in Zebrafish Causes Long-Term Adult Behavioral Impairment with Indications of Embyronic Synaptic Changes, Nicole M. Roy, Brianna Arpie, Joseph Lugo, Elwood Linney, Edward D. Levin, Daniel Cerutti
Nicole M. Roy

Dynamic Glucoregulation and Mammalian-Like Responses to Metabolic and Developmental Disruption in Zebrafish, Agata Jurczyk, Nicole M. Roy, Rabia Bajwa, Philipp Gut, Kathryn Lipson, Chaoxing Yang, Laurence Covassin, Waldemar J. Racki, Aldo A. Rossini, Nancy Phillips, Didier Y. R. Stainier, Dale L. Greiner, Michael A. Brehm, Rita Bortell, Philip Diiorio
Nicole M. Roy

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast, Benjamin J. Alper, Godwin Job, Rajesh K. Yadav, Sreenath Shanker, Brandon R. Lowe, Janet F. Partridge
Benjamin Alper

Using RNAi in C. elegans to Demonstrate Gene Knockdown Phenotypes in the Undergraduate Biology Lab Setting, Nicole M. Roy
Biology Faculty Publications

Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure, Reuben Thomas, Julia M. Gohlke, Geffrey F. Stopper, Frederick M. Parham, Christopher J. Portier
Geffrey F. Stopper

Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy., Christopher M. Bailey, Todd J. Sullivan, Pinar Iyidogan, Julian Tirado-Rives, Raymond Chung, Juliana Ruiz-Caro, Ebrahim Mohamed, William L. Jorgensen, Roger Hunter, Karen S. Anderson
Todd J. Sullivan

Sir2 is Required for Clr4 to Initiate Centromeric Heterochromatin Assembly in Fission Yeast, Benjamin J. Alper, Godwin Job, Rajesh K. Yadav, Sreenath Shanker, Brandon R. Lowe, Janet F. Partridge
Chemistry & Physics Faculty Publications

Evaluating amyloid beta (Aβ) 1-40 degradation by capillary electrophoresis., Benjamin J. Alper, Walter K. Schmidt
Benjamin Alper

Evaluating Amyloid Beta (Aβ) 1-40 Degradation by Capillary Electrophoresis, Benjamin J. Alper, Walter K. Schmidt
Chemistry & Physics Faculty Publications

Cell-Permeable, Small-Molecule Activators of the Insulin-Degrading Enzyme, Sayali S. Kukday, Surya P. Manandhar, Marissa C. Ludley, Mary E. Burriss, Benjamin J. Alper, Walter K. Schmidt
Chemistry & Physics Faculty Publications

Centromeric Heterochromatin Assembly in Fission Yeast-Balancing Transcription, RNA Interference and Chromatin Modification, Benjamin Alper, Brandon R. Lowe, Janet F. Partridge
Chemistry & Physics Faculty Publications

Cell-permeable, small-molecule activators of the insulin-degrading enzyme, Sayali S. Kukday, Surya P. Manandhar, Marissa C. Ludley, Mary E. Burriss, Benjamin J. Alper, Walter K. Schmidt
Benjamin Alper

A Self-Assembling Polypeptide Nanoparticle Vaccine for Avian Influenza, Tobias Neef, Sankhiros Babapoor, Christian Mittelholzer, Senthil Raman, Mazar Khan, Peter Burkhard
Sankhiros Babapoor

Anion activation site of insulin-degrading enzyme, Nicholas Noinaj, Eun Suk Song, Sonia Bhasin, Benjamin J. Alper, Walter K. Schmidt, Louis B. Hersh, David W. Rodgers
Benjamin Alper

Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification, Benjamin J. Alper, Brandon R. Lowe, Janet F. Partridge
Benjamin Alper

Anion Activation Site of Insulin-Degrading Enzyme, Nicholas Noinaj, Eun Suk Song, Sonia Bhasin, Benjamin J. Alper, Walter K. Schmidt, Louis B. Hersh, David W. Rodgers
Chemistry & Physics Faculty Publications

Dietary Energy Density Is Associated with Body Weight Status and Vegetable Intake in U.S. Children, Jacqueline A. Vernarelli, Diane C. Mitchell, Terryl J. Hartman, Barbara J. Rolls
Jacqueline A. Vernarelli

Dynamic Glucoregulation and Mammalian-Like Responses to Metabolic and Developmental Disruption in Zebrafish, Agata Jurczyk, Nicole M. Roy, Rabia Bajwa, Philipp Gut, Kathryn Lipson, Chaoxing Yang, Laurence Covassin, Waldemar J. Racki, Aldo A. Rossini, Nancy Phillips, Didier Y. R. Stainier, Dale L. Greiner, Michael A. Brehm, Rita Bortell, Philip Diiorio
Biology Faculty Publications

The Synergistic Use of Computation, Chemistry and Biology to Discover Novel Peptide-Based Drugs: The Time is Right, Joseph Audie, C. Boyd
Chemistry & Physics Faculty Publications

Yeast Ste23p Shares Functional Similarities with Mammalian Insulin-Degrading Enzymes, Benjamin Alper, Jarrad W. Rowse, Walter K. Schmidt
Chemistry & Physics Faculty Publications

Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1, Florian S. Eichler, Thorsten Hornemann, Alex McCampbell, Dika Kuljis, Anke Penno, Daniel Vardeh, Eric Tamrazian, Kevin Garofalo, Ho-Joon Lee, Lohit Kini, Martin Selig, Matthew Frosch, Ken Gable, Arnold von Eckardstein, Clifford J. Woolf, Guiman Guan, Jeffrey M. Harmon, Teresa M. Dunn, Robert H. Brown
Dika Kuljis

A Capillary Electrophoresis Method for Evaluation of Abeta Proteolysis in Vitro, Benjamin J. Alper, Walter K. Schmidt
Chemistry & Physics Faculty Publications

Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure, Reuben Thomas, Julia M. Gohlke, Geffrey F. Stopper, Frederick M. Parham, Christopher J. Portier
Biology Faculty Publications

Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes, Benjamin J. Alper, Jarrad W. Rowse, Walter K. Schmidt
Benjamin Alper

A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro, Benjamin J. Alper, Walter K. Schmidt
Benjamin Alper

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors, Christopher W. am Ende, Susan E. Knudson, Nina Liu, James Childs, Todd J. Sullivan, Melissa Boyne, Hua Xu, Yelizaveta Gegina, Dennis L. Knudson, Francis Johnson, Charles A. Peloquin, Richard A. Slayden, Peter J. Tonge
Todd J. Sullivan

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus., Hua Xu, Todd J. Sullivan, Jun-ichiro Sekiguchi, Teruo Kirikae, Iwao Ojima, Christopher F. Stratton, Weimin Mao, Fernando L. Rock, M. R. K. Alley, Francis Johnson, Stephen G. Walker, Peter J. Tonge
Todd J. Sullivan

Mutations Affecting a Putative MutLa Endonuclease Motif Impact Multiple DNA Mismatch Repair Functions, Naz Erdeniz, Megan Nguyen, Suzanne M. Deschênes, R. Michael Liskay
Biology Faculty Publications

Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors, Melissa E. Boyne, Todd J. Sullivan, Christopher W. amEnde, Hao Lu, Veronica Gruppo, Darragh Heaslip, Anita G. Amin, Delphi Chatterjee, Anne Lenaerts, Peter J. Tonge, Richard A. Slayden
Todd J. Sullivan

The Kinetic Studies of saFabI, the Enoyl ACP Reductase From Staphylococcus aureus, Hua Xu, Todd Sullivan, Teruo Kirikae, Peter J. Tonge
Todd J. Sullivan

A Common Genetic System for Functional Studies of Pitrilysin and Related M16A Proteases, Benjamin J. Alper, Tatyana E. Nienow, Walter K. Schmidt
Chemistry & Physics Faculty Publications

A common genetic system for functional studies of pitrilysin and related M16A proteases, Benjamin J. Alper, Tatyana E. Nienow, Walter K. Schmidt
Benjamin Alper

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis, Todd J. Sullivan, James J. Truglio, Melissa E. Boyne, Polina Novichenok, Xujie Zhang, Christopher F. Stratton, Huei-Jiun Li, Tejinder Kaur, Amol Amin, Francis Johnson, Richard A. Slayden, Caroline Kisker, Peter J. Tonge
Todd J. Sullivan

Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues., Sharada Sivaraman, Todd J. Sullivan, Francis Johnson, Polina Novichenok, Guanglei Cui, Carlos Simmerling, Peter J. Tonge
Todd J. Sullivan

Intracellular Transport, Assembly, and Degradation of Wild-Type and Disease-linked Mutant Gap Junction Proteins, Judy K. VanSlyke, Suzanne M. Deschênes, Linda S. Musil
Biology Faculty Publications

The Polarized Sorting of Membrane Proteins Expressed in Cultured Hippocampal Neurons Using Viral Vectors, Mark Jareb, Gary Banker
Biology Faculty Publications

Biochemical and Morphometric Studies of Heart, Liver and Skeletal muscle from the Hibernating, Arousing and Aroused Big Brown Bat, Eptesicus fuscus, Margaret L. Fonda, George H. Herbener, Robert W. Cuddihee
Chemistry & Physics Faculty Publications