Document Type

Peer-Reviewed Article

Publication Date

2-2017

Abstract

Epilepsy is the fourth most common neurological disorder and affects more than 65 million individuals worldwide.This condition is marked by the presence of epileptic seizures, which result from an abnormal synchronous firing of excitatory neurons in the brain. When neurons fire synchronously, a wave of depolarization known as a paroxysmal depolarizing shift occurs. During this period, the neurons experience a lowered resistance to firing, leading to multiple action potentials that generate abnormally increased electrical activity within the brain.

Comments

Drug Forecast column.

PMC Free full text.

PMID

28163554

Publication

P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management

Volume

42

Issue

2

Pages

92-96

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