Epilepsy is the fourth most common neurological disorder and affects more than 65 million individuals worldwide.This condition is marked by the presence of epileptic seizures, which result from an abnormal synchronous firing of excitatory neurons in the brain. When neurons fire synchronously, a wave of depolarization known as a paroxysmal depolarizing shift occurs. During this period, the neurons experience a lowered resistance to firing, leading to multiple action potentials that generate abnormally increased electrical activity within the brain.
Khaleghi, F., & Nemec, E. C. (2017). Brivaracetam (Briviact): A novel adjunctive therapy for partial-onset seizures. P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management, 42(2), 92-96.
P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management