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Regional policy instruments are typically driven by economic rationales, from either a firm or industrial perspective. Yet too often, these rationales are taken as ex ante to the contexts within which firms and industries compete. Recent regional development research has urged a better link be developed between the individual, the firm, and their context, so as to understand the role of regions in supporting effective competitiveness of organizations. In this article, recent research themes are explored that may shed light on the nature of this relationship and that can be developed into an investigative methodology that could aid policy practitioners in generating policy instruments that reflect differing societal constructions of SME reality.