Mentor/s
Professor Mark Jareb
Participation Type
Poster
Abstract
The correct targeting of proteins to axons and dendrites of neurons is essential for the proper development of the nervous system. L1CAM is a cell-adhesion molecule responsible for multiple aspects of neuronal development; mutations are known to result in a developmental syndrome characterized by cognitive and motor disabilities. We expressed wild-type L1CAM and known L1CAM mutant proteins, P941L and D544N, in cultured embryonic chick forebrain neurons and compared their cellular distributions. Preliminary data suggests that both the wild-type L1CAM and the P941L L1CAM mutant are targeted to axons in a similar fashion. In contrast, the D544N L1CAM mutant does not appear to reach the cell surface of the neuron.
College and Major available
Biology
Location
University Commons
Start Day/Time
4-20-2018 1:00 PM
End Day/Time
4-20-2018 3:00 PM
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Comparison of Wild-Type versus Mutant L1CAM Expression in Cultured Neurons
University Commons
The correct targeting of proteins to axons and dendrites of neurons is essential for the proper development of the nervous system. L1CAM is a cell-adhesion molecule responsible for multiple aspects of neuronal development; mutations are known to result in a developmental syndrome characterized by cognitive and motor disabilities. We expressed wild-type L1CAM and known L1CAM mutant proteins, P941L and D544N, in cultured embryonic chick forebrain neurons and compared their cellular distributions. Preliminary data suggests that both the wild-type L1CAM and the P941L L1CAM mutant are targeted to axons in a similar fashion. In contrast, the D544N L1CAM mutant does not appear to reach the cell surface of the neuron.
