Professor Mark Jareb

Participation Type


College and Major available



University Commons

Start Day/Time

4-20-2018 1:00 PM

End Day/Time

4-20-2018 3:00 PM


Apr 20th, 1:00 PM Apr 20th, 3:00 PM

Comparison of Wild-Type versus Mutant L1CAM Expression in Cultured Neurons

University Commons

The correct targeting of proteins to axons and dendrites of neurons is essential for the proper development of the nervous system. L1CAM is a cell-adhesion molecule responsible for multiple aspects of neuronal development; mutations are known to result in a developmental syndrome characterized by cognitive and motor disabilities. We expressed wild-type L1CAM and known L1CAM mutant proteins, P941L and D544N, in cultured embryonic chick forebrain neurons and compared their cellular distributions. Preliminary data suggests that both the wild-type L1CAM and the P941L L1CAM mutant are targeted to axons in a similar fashion. In contrast, the D544N L1CAM mutant does not appear to reach the cell surface of the neuron.


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