Mentor/s
Dr. Benjamin Alper
Participation Type
Paper Talk
Abstract
Angiotensin-converting enzyme I (ACE) is a zinc- and chloride-dependent carboxypeptidase. In mammals, there are two isozymes of ACE: somatic ACE (sACE) and germinal ACE (gACE). Generally, ACE affects numerous mammalian processes, including renal development, male fertility, hematopoiesis, erythropoiesis, myelopoiesis, and immune responses, although the mechanism(s) are not well-known. The specific role(s) and mechanism(s) of gACE have not been elucidated, with sACE having a far more expansive body of literature—thus, human sACE will be the primary focus of this Review. Human sACE is primarily involved in blood pressure regulation via degradation of bradykinin (BK) and conversion of angiotensin I (Ang I) to angiotensin II (Ang II) in the renin-angiotensin-aldosterone system (RAAS). The discovery and development of angiotensin-converting enzyme I inhibitors (ACEIs) have been a ‘miracle drug’ for treating hypertension (either primarily or as a symptom of another disease), but they are not without side effects. However, it has been speculated that improving specificity of ACEIs towards a specific catalytic domain of sACE would decrease the prevalence of side effects.
College and Major available
Chemistry
Location
Session 6: Digital Commons & West Campus West Building Room 133
Start Day/Time
4-26-2024 9:00 AM
End Day/Time
4-26-2024 10:15 AM
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Prize Categories
Most Scholarly Impact or Potential, Best Visuals, Most Creative
Angiotensin-Converting Enzyme I: A Review of Current Literature
Session 6: Digital Commons & West Campus West Building Room 133
Angiotensin-converting enzyme I (ACE) is a zinc- and chloride-dependent carboxypeptidase. In mammals, there are two isozymes of ACE: somatic ACE (sACE) and germinal ACE (gACE). Generally, ACE affects numerous mammalian processes, including renal development, male fertility, hematopoiesis, erythropoiesis, myelopoiesis, and immune responses, although the mechanism(s) are not well-known. The specific role(s) and mechanism(s) of gACE have not been elucidated, with sACE having a far more expansive body of literature—thus, human sACE will be the primary focus of this Review. Human sACE is primarily involved in blood pressure regulation via degradation of bradykinin (BK) and conversion of angiotensin I (Ang I) to angiotensin II (Ang II) in the renin-angiotensin-aldosterone system (RAAS). The discovery and development of angiotensin-converting enzyme I inhibitors (ACEIs) have been a ‘miracle drug’ for treating hypertension (either primarily or as a symptom of another disease), but they are not without side effects. However, it has been speculated that improving specificity of ACEIs towards a specific catalytic domain of sACE would decrease the prevalence of side effects.
Students' Information
Victoria Tabulov '24, Biochemistry with minors in Honors, Psychology, and Physics