Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure

Authors

Reuben Thomas
Julia M. Gohlke
Geffrey F. Stopper, Sacred Heart UniversityFollow
Frederick M. Parham
Christopher J. Portier

Document Type

Peer-Reviewed Article

Publication Date

2009

Abstract

A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results.

Comments

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2009/10/4/R44

DOI

10.1186/gb-2009-10-4-r44

Recommended Citation

Thomas, Reuben, Geffrey Stopper et al. "Choosing the Right Path: Enhancement of Biologically Relevant Sets of Genes or Proteins Using Pathway Structure." Genome Biology 10.R44 (2009): R44.