Using Factorial Design to Determine Which Factors Affect the Yield of the Microwave-Assisted Oxidation of 1-Indanol

Date of Award


Degree Type


Degree Name

Master of Science (MS)



First Advisor

Linda Farber, Ph.D.


Over recent years, microwave oxidation reactions have gained significance as both researchers and manufacturers look for the eco-friendly and efficient methods of organic synthesis. Microwaves accelerate organic reactions considerably, and it is now the most effective way of organic synthesis.¹ Most manufacturing firms and researchers have taken up microwave synthesis due to its effectiveness and reliance as compared to traditional modes of synthesis.¹ This research focuses on using Factorial Design to determine which factors affect the yield of the microwave oxidation of 1-Indanol (1) to 1-Indanone using polymer-supported chromic acid in methylene chloride. Formation of 1-Indanone (2) is important due to its wide use in pharmaceutical manufacturing.² Factorial design is important due to its ability to investigate cause-and-effect relationships of significance in a given experimental setting and it has been exponentially used in organic chemistry.³̕⁴The [sic] reaction was studied various times with varying wattage, time and temperature.̕According to Multilevel Factorial Design used, it was found that irradiation for ten minutes along with temperature of 120°C and 1200W gave highest yield and best results by using 650 mg of chromium trioxide resin.


Master's thesis submitted to the faculty of Sacred Heart University's Chemistry Program in partial fulfillment of the requirements for the degree of Master of Chemistry.