Document Type
Peer-Reviewed Article
Publication Date
7-2023
Abstract
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.
DOI
10.1016/j.biopha.2023.114822
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Pavitra, E., Kancharla, J., Gupta, V. K., Prasad, K., Sung, J. Y., Kim, J., ... & Huh, Y. S. (2023). The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy. Biomedicine & Pharmacotherapy, 163, 114822. https://doi.org/10.1016/j.biopha.2023.114822
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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Health Information Technology Commons, Neoplasms Commons
