Document Type
Peer-Reviewed Article
Publication Date
2023
Abstract
Telomere shortening is a biological aging hallmark. The effect of short telomere length may be targeted by increased physical activity to reduce the risk of multiple aging-related diseases, including coronary heart disease (CHD). The objective was to assess the moderation effect of accelerometer-based physical activity (aPA) on the association between shorter leukocyte telomere length (LTL) relatively in the population sample and incident CHD. Data were from the UK Biobank participants with well-calibrated accelerometer data for at least 6.5 days (n = 54,180). Relative mean LTL at baseline (5–6 years prior to aPA assessment) was measured in T/S ratio, using a multiplex quantitative polymerase chain reaction (qPCR) technology, by comparing the amount of the telomere amplification product (T) to that of a single-copy gene (S). aPA measures included total number of events (at least 10-s continued physical activity > 32 milligravities [mg]), total volume, mean duration, mean intensity, and peak intensity of all events. LTL, aPA measures, and their interactions were associated with incident CHD (mean follow-up 6.8 years) using Cox proportional hazards models adjusting for covariates. Longer LTL (relative to the sample distribution) was associated with reduced incidence of CHD (adjusted hazard ratio [aHR] = 0.94 per standard deviation [SD] increase in LTL, [95% CI, 0.90 to 0.99], P = .010). Incidence of CHD was reduced by higher total volume of aPA (aHR = 0.82 per SD increase in LTL, [95% CI, 0.71 to 0.95], P = .010) but increased by higher total number of events (aHR = 1.11 per SD increase in LTL, [95% CI, 1.02 to 1.21], P = .020) after controlling for other aPA measures and covariates. However, none of the interactions between LTL and aPA measures was statistically significant (P = .171).
DOI
10.1007/s11357-023-00890-7
PMID
37544968
Recommended Citation
Lee, Y., Park, K., Melzer, D., Kirk, B., Duque, G., Liu, R., Kuchel, G. A., Wood, A.R., Diniz, B.S., Hillsdon, M., & Kuo, C.L. (2008). Does physical activity moderate the association between depressive symptoms and disability in older adults? GeroScience. Doi: 10.1007/s11357-023-00890-7
Publication
GeroScience
Publisher
Springer Nature
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
This article is open access under a Creative Commons Attribution 4.0 International License