Document Type
Peer-Reviewed Article
Publication Date
3-2021
Abstract
Infertility affects nearly 50 million couples worldwide, with 40−50% of cases having a male factor component. It is well established that nutritional status impacts reproductive development, health and function, although the exact mechanisms have not been fully elucidated. Genetic variation that affects nutrient metabolism may impact fertility through nutrigenetic mechanisms. This review summarizes current knowledge on the role of several dietary components (vitamins A, B12, C, D, E, folate, betaine, choline, calcium, iron, caffeine, fiber, sugar, dietary fat, and gluten) in male reproductive health. Evidence of gene-nutrient interactions and their potential effect on fertility is also examined. Understanding the relationship between genetic variation, nutrition and male fertility is key to developing personalized, DNA-based dietary recommendations to enhance the fertility of men who have difficulty conceiving.
DOI
10.21037/tau-20-592
PMID
33850777
Recommended Citation
Vanderhout, S. M., Panah, M. R., Garcia-Bailo, B., Grace-Farfaglia, P., Samsel, K., Dockray, J., Jarvi, K., & El-Sohemy, A. (2021). Nutrition, genetic variation and male fertility. Translational Andrology and Urology, 10(3), 1410. Doi: 10.21037/TAU-20-592
Publication
Translational Andrology and Urology
Volume
10
Issue
3
Publisher
AME Publishing Company
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
Comments
This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0)