Enteric Absorption of Ciprofloxacin During Tube Feeding in the Critically Ill

Authors

Stephen M. Cohn
Mark D. Sawyer
Gerard A. Burns
Concertina Tolomeo
Kerry A. Milner, Sacred Heart UniversityFollow

Document Type

Article

Publication Date

11-1996

Abstract

To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during entcral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24–3.06 mg/L, and the area under the time curve from 0–12 h ranged from 3.2–19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.

Comments

At the time of publication, Kerry Milner was affiliated with Section of Trauma/Surgical Critical Care, Department of Surgery, Yale School of Medicine.

DOI

10.1093/jac/38.5.871

Recommended Citation

Cohn, Stephen M. et. al. "Enteric Absorption of Ciprofloxacin During Tube Feeding in the Critically Ill." Journal of Antimicrobial Chemotherapy 38.5 (1996): 871-876.