Mentor/s
Dr.Mark Jareb
Participation Type
Poster
Abstract
Protein Targeting of Amyloid Precursor Protein in Cultured Neurons
The amyloid precursor protein (APP) is widely expressed in the central nervous system and appears to play a key role in the pathogenesis of Alzheimer’s disease. Understanding the normal targeting and processing of the APP protein in neurons will provide insight into the mechanisms that result in the pathophysiology associated with Alzheimer’s. We have expressed a FLAG-tagged human APP construct in cultured and visualized its distribution using immunocytochemistry. Preliminary data suggests that the APP protein is expressed in both the somatodendritic (cell body and dendrites) domain and axons of the cultured chick neurons consistent with data in other systems.
College and Major available
Biology, Neuroscience
Location
Digital Commons & West Campus West Building
Start Day/Time
4-29-2022 1:00 PM
End Day/Time
4-29-2022 4:00 PM
Prize Categories
Most Scholarly Impact or Potential, Best Visuals, Most Creative
Protein Targeting of Amyloid Precursor Protein in Cultured Neurons
Digital Commons & West Campus West Building
Protein Targeting of Amyloid Precursor Protein in Cultured Neurons
The amyloid precursor protein (APP) is widely expressed in the central nervous system and appears to play a key role in the pathogenesis of Alzheimer’s disease. Understanding the normal targeting and processing of the APP protein in neurons will provide insight into the mechanisms that result in the pathophysiology associated with Alzheimer’s. We have expressed a FLAG-tagged human APP construct in cultured and visualized its distribution using immunocytochemistry. Preliminary data suggests that the APP protein is expressed in both the somatodendritic (cell body and dendrites) domain and axons of the cultured chick neurons consistent with data in other systems.
Students' Information
Maria Hatziminadakis
Neuroscience
Year of graduation: 2022