First and Last Name/s of Presenters

Maria HatziminadakisFollow

Mentor/s

Dr.Mark Jareb

Participation Type

Poster

Abstract

Protein Targeting of Amyloid Precursor Protein in Cultured Neurons

The amyloid precursor protein (APP) is widely expressed in the central nervous system and appears to play a key role in the pathogenesis of Alzheimer’s disease. Understanding the normal targeting and processing of the APP protein in neurons will provide insight into the mechanisms that result in the pathophysiology associated with Alzheimer’s. We have expressed a FLAG-tagged human APP construct in cultured and visualized its distribution using immunocytochemistry. Preliminary data suggests that the APP protein is expressed in both the somatodendritic (cell body and dendrites) domain and axons of the cultured chick neurons consistent with data in other systems.

College and Major available

Biology, Neuroscience

Location

Digital Commons & West Campus West Building

Start Day/Time

4-29-2022 1:00 PM

End Day/Time

4-29-2022 4:00 PM

Students' Information

Maria Hatziminadakis

Neuroscience

Year of graduation: 2022

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Apr 29th, 1:00 PM Apr 29th, 4:00 PM

Protein Targeting of Amyloid Precursor Protein in Cultured Neurons

Digital Commons & West Campus West Building

Protein Targeting of Amyloid Precursor Protein in Cultured Neurons

The amyloid precursor protein (APP) is widely expressed in the central nervous system and appears to play a key role in the pathogenesis of Alzheimer’s disease. Understanding the normal targeting and processing of the APP protein in neurons will provide insight into the mechanisms that result in the pathophysiology associated with Alzheimer’s. We have expressed a FLAG-tagged human APP construct in cultured and visualized its distribution using immunocytochemistry. Preliminary data suggests that the APP protein is expressed in both the somatodendritic (cell body and dendrites) domain and axons of the cultured chick neurons consistent with data in other systems.

 

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