Mentor/s
Dr. Rachel Bowman
Participation Type
Poster
Abstract
Bisphenol-A (BPA) is an endocrine disruptor that regulates the effects of estrogenic, androgenic, and antiandrogenic systems. BPA is extensively used in the manufacturing of hard plastics leading to detectable BPA levels in body fluids of humans and animals indicating that BPA exposure is ubiquitous and has potential health hazards. The purpose of this study was to investigate the effects of adolescent exposure to low-dose BPA via oral ingestion in water on behavior and neuronal morphology in intact adolescent male rats. The dose given, a concentration equivalent to 40/µg/kg/day, is lower than daily safe-dose levels set by the United States Environmental Protection Agency (1993). Results showed that BPA had no behavioral effects. Anxiety was measured using an Elevated Plus Maze (EPM) and Open Field (OF) tests. On the EPM, results showed that most rats made equal visits to the closed and open as well as the OF where all rats visited the outer sectors more frequently than inner visits with no treatment effects. Object placement and recognition tests were used to measure cognitive function and results showed no significant difference between treatment groups. These results differ from past work in our lab following adolescent BPA exposure via injection. Thus, the route of administration and dosage of BPA appears to have differential effects on physiological and cognitive measures.
College and Major available
Neuroscience
Location
Digital Commons & West Campus 2nd Floor University Commons
Start Day/Time
4-28-2023 12:00 PM
End Day/Time
4-28-2023 2:00 PM
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Prize Categories
Best Multidisciplinary Research or Collaboration, Most Scholarly Impact or Potential, Best Visuals
Low-Dose Drinking Water Bisphenol-A Does Not Alter Anxiety or Cognitive Functioning in Adolescent Male Rats
Digital Commons & West Campus 2nd Floor University Commons
Bisphenol-A (BPA) is an endocrine disruptor that regulates the effects of estrogenic, androgenic, and antiandrogenic systems. BPA is extensively used in the manufacturing of hard plastics leading to detectable BPA levels in body fluids of humans and animals indicating that BPA exposure is ubiquitous and has potential health hazards. The purpose of this study was to investigate the effects of adolescent exposure to low-dose BPA via oral ingestion in water on behavior and neuronal morphology in intact adolescent male rats. The dose given, a concentration equivalent to 40/µg/kg/day, is lower than daily safe-dose levels set by the United States Environmental Protection Agency (1993). Results showed that BPA had no behavioral effects. Anxiety was measured using an Elevated Plus Maze (EPM) and Open Field (OF) tests. On the EPM, results showed that most rats made equal visits to the closed and open as well as the OF where all rats visited the outer sectors more frequently than inner visits with no treatment effects. Object placement and recognition tests were used to measure cognitive function and results showed no significant difference between treatment groups. These results differ from past work in our lab following adolescent BPA exposure via injection. Thus, the route of administration and dosage of BPA appears to have differential effects on physiological and cognitive measures.
Students' Information
Abigail Andre, Neuroscience, 2023
Nicole Alvira, Psychology, 2023
Teresina Berni, Neuroscience and Mathematics, 2023
Lauren Maiolo, Psychology, 2023
Alexandra Piasecki, Psychology, 2023