Mentor/s
Dr. Matthew Moran Dr. Joshua Lander
Participation Type
Poster
Abstract
INTRODUCTION: Parkinson Disease (PD) is the second most common neurodegenerative disease, affecting 1-3% of the population over the age of 601, increasing 2.5-fold in prevalence over the last generation.2 The Timed Up-and-Go (TUG) Test is a common screening tool used for lower extremity function, mobility, and fall-risk. The assessments requires an individual to complete a sit-stand movement, initiate gait, walk three meters, turn 180 degrees, walk three meters back, and sit down.8A completion time > 12 seconds is associated with an increased risk of falling.
PURPOSE: Assess the correlation between cognitive status and total time and phase time of the TUG test within a sample of individuals with PD. It was hypothesized that those with a slower performance in the sit-to-walk temporal phase12 turning phases would score lower on visuospatial cognitive skill tasks. Additionally, it was hypothesized that PD individuals with poorer motor function but expressing a non-tremor phenotype may perform a slower TUG and display greater cognitive deficits.
METHODS: Participants were evaluated with the Unified Parkinson’s Disease Rating Scale (UPDRS) Part 3 (motor) and screened with the PHQ-9 and MoCA tests. Cognitive assessments were attained using a validated software program (Creyos; Toronto, Canada) to test working memory, response inhibition, and visuospatial processing. All current medications were reported, and maintenance of normal medication schedule was advised. Each participant performed two TUG trials that were assessed with a video-based three-dimensional marker-less motion capture analysis system. Pearson correlation tests were run using MS Excel between the participant’s fastest TUG trial phase times compared to cognitive scores. Criterion for statistical significance was set apriori at p < 0.05.15
RESULTS: Total TUG completion time averaged 10.97 ± 2.07 seconds. Statistical significance was shown between the Creyo’s cognitive domain tests, Double Trouble (13.7 ± 14.1), Token Search (4.7 ± 1.2), Rotations (56.5 ± 30.6), and time of Sit-to-Stand (1.14 ± 0.30 s), Walk 1 (1.72 ± 0.23 s), Turn Around (2.99 ± 0.61 s), and Walk 2 (1.89 ± 0.34 s) phases, respectively. The most linear relationship shown between increased phase time and visuospatial activities.
DISCUSSION: In order to perform mental rotations, the individual must be able to disengage from the original stimulus, which requires an input of dopamine.17 Crucian et al. determined that dopamine-medication either has a very small or no effect on the ability to perform free-vision mental rotations in individuals with PD.
College and Major available
Exercise Science BS
Location
Digital Commons & West Campus 2nd Floor University Commons
Start Day/Time
4-28-2023 12:00 PM
End Day/Time
4-28-2023 2:00 PM
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Prize Categories
Best Multidisciplinary Research or Collaboration, Most Scholarly Impact or Potential, Best Writing
Correlates of Timed-Up-and-Go Temporal Metrics with Cognitive Status in Individuals with Parkinson Disease
Digital Commons & West Campus 2nd Floor University Commons
INTRODUCTION: Parkinson Disease (PD) is the second most common neurodegenerative disease, affecting 1-3% of the population over the age of 601, increasing 2.5-fold in prevalence over the last generation.2 The Timed Up-and-Go (TUG) Test is a common screening tool used for lower extremity function, mobility, and fall-risk. The assessments requires an individual to complete a sit-stand movement, initiate gait, walk three meters, turn 180 degrees, walk three meters back, and sit down.8A completion time > 12 seconds is associated with an increased risk of falling.
PURPOSE: Assess the correlation between cognitive status and total time and phase time of the TUG test within a sample of individuals with PD. It was hypothesized that those with a slower performance in the sit-to-walk temporal phase12 turning phases would score lower on visuospatial cognitive skill tasks. Additionally, it was hypothesized that PD individuals with poorer motor function but expressing a non-tremor phenotype may perform a slower TUG and display greater cognitive deficits.
METHODS: Participants were evaluated with the Unified Parkinson’s Disease Rating Scale (UPDRS) Part 3 (motor) and screened with the PHQ-9 and MoCA tests. Cognitive assessments were attained using a validated software program (Creyos; Toronto, Canada) to test working memory, response inhibition, and visuospatial processing. All current medications were reported, and maintenance of normal medication schedule was advised. Each participant performed two TUG trials that were assessed with a video-based three-dimensional marker-less motion capture analysis system. Pearson correlation tests were run using MS Excel between the participant’s fastest TUG trial phase times compared to cognitive scores. Criterion for statistical significance was set apriori at p < 0.05.15
RESULTS: Total TUG completion time averaged 10.97 ± 2.07 seconds. Statistical significance was shown between the Creyo’s cognitive domain tests, Double Trouble (13.7 ± 14.1), Token Search (4.7 ± 1.2), Rotations (56.5 ± 30.6), and time of Sit-to-Stand (1.14 ± 0.30 s), Walk 1 (1.72 ± 0.23 s), Turn Around (2.99 ± 0.61 s), and Walk 2 (1.89 ± 0.34 s) phases, respectively. The most linear relationship shown between increased phase time and visuospatial activities.
DISCUSSION: In order to perform mental rotations, the individual must be able to disengage from the original stimulus, which requires an input of dopamine.17 Crucian et al. determined that dopamine-medication either has a very small or no effect on the ability to perform free-vision mental rotations in individuals with PD.
Students' Information
Hannah Alexanian is a Class of 2023 Exercise Science 3+3 Physical Therapy student in the Thomas More Honors Program.
Other things she has done: Exercise Science Club, President Pre-PT Club, Vice President Exercise Physiology CLA Sports Medicine CLA Strength & Conditioning CLA Biology Learning Lab Tutor Chi Omega Fraternity, Treasurer 2022 Rise Program Fitness Buddy
Honorable Mention, Most Scholarly Impact or Potential 2023 Award