Oxidation of Benzhydrol to Benzophenone through the Optimization of Various Parameters in Microwave Irradiation

Date of Award

6-2020

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Dr. Linda Farber

Abstract

Microwave irradiation can increase the speed of a reaction and cause different amounts of product to be formed through the varying of three key parameters: temperature, time, and wattage. The oxidation reaction of benzhydrol with chromium trioxide resin (polymer-supported chromic acid) in dichloromethane under varying conditions of time, temperature, and wattage was studied. After completing 96 experiments with various parameter combinations using microwave-assisted synthesis, the data was analyzed using a factorial design analysis software. Minitab, to determine which parameter(s) had the largest effect on the amount of benzophenone produced. The percent conversion of benzophenone was determined by ¹H-NMR analysis. The data shows that temperature has the most effect on the percent conversion to benzophenone, while time and wattage show no direct effect on percent conversion.

Comments

Master's thesis submitted to the Faculty of the Department of Chemistry at Sacred Heart University in partial fulfillment of the requirements for the degree of Master of Science.

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